Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9
About this item
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Author / Creator
Schneider, Rebekka K , Schenone, Monica , Ferreira, Monica Ventura , Kramann, Rafael , Joyce, Cailin E , Hartigan, Christina , Beier, Fabian , Brümmendorf, Tim H , Germing, Ulrich , Platzbecker, Uwe , Büsche, Guntram , Knüchel, Ruth , Chen, Michelle C , Waters, Christopher S , Chen, Edwin , Chu, Lisa P , Novina, Carl D , Lindsley, R Coleman , Carr, Steven A and Ebert, Benjamin L
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
In a mouse model of the 5q- subtype of myelodysplastic syndrome, haploinsufficiency of the ribosomal protein gene
Rps14
leads to anemia through a mechanism involving innate immune signaling and the Tlr4 ligand S100A8, which induces a p53-dependent block to erythroid differentiation.
Impaired erythropoiesis in the deletion 5q (del(5q)) subt...
Alternative Titles
Full title
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9
Authors, Artists and Contributors
Author / Creator
Schenone, Monica
Ferreira, Monica Ventura
Kramann, Rafael
Joyce, Cailin E
Hartigan, Christina
Beier, Fabian
Brümmendorf, Tim H
Germing, Ulrich
Platzbecker, Uwe
Büsche, Guntram
Knüchel, Ruth
Chen, Michelle C
Waters, Christopher S
Chen, Edwin
Chu, Lisa P
Novina, Carl D
Lindsley, R Coleman
Carr, Steven A
Ebert, Benjamin L
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4870050
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4870050
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X
DOI
10.1038/nm.4047
