Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity
Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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The cancer stem cells (CSCs) of glioblastoma multiforme (GBM), a grade IV astrocytoma, have been enriched by the expressed marker CD133. However, recent studies have shown that CD133⁻ cells also possess tumor-initiating potential. By analysis of gangliosides on various cells, we show that ganglioside D3 (GD3) is overexpressed on eight neurospheres...
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Full title
Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4878508
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4878508
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1604721113
