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Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades

Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4883652

Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades

About this item

Full title

Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades

Publisher

United States: American Association for the Advancement of Science

Journal title

Science (American Association for the Advancement of Science), 2015-09, Vol.349 (6255), p.1525-1529

Language

English

Formats

Publication information

Publisher

United States: American Association for the Advancement of Science

More information

Scope and Contents

Contents

α-Chiral amines are key intermediates for the synthesis of a plethora of chemical compounds at industrial scale. We present a biocatalytic hydrogen-borrowing amination of primary and secondary alcohols that allows for the efficient and environmentally benign production of enantiopure amines. The method relies on a combination of two enzymes: an alc...

Alternative Titles

Full title

Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4883652

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4883652

Other Identifiers

ISSN

0036-8075

E-ISSN

1095-9203

DOI

10.1126/science.aac9283

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