Log in to save to my catalogue

Phase separation of signaling molecules promotes T cell receptor signal transduction

Phase separation of signaling molecules promotes T cell receptor signal transduction

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4892427

Phase separation of signaling molecules promotes T cell receptor signal transduction

About this item

Full title

Phase separation of signaling molecules promotes T cell receptor signal transduction

Publisher

United States: American Association for the Advancement of Science

Journal title

Science (American Association for the Advancement of Science), 2016-04, Vol.352 (6285), p.595-599

Language

English

Formats

Publication information

Publisher

United States: American Association for the Advancement of Science

More information

Scope and Contents

Contents

Activation of various cell surface receptors triggers the reorganization of downstream signaling molecules into micrometer- or submicrometer-sized clusters. However, the functional consequences of such clustering have been unclear. We biochemically reconstituted a 12-component signaling pathway on model membranes, beginning with T cell receptor (TC...

Alternative Titles

Full title

Phase separation of signaling molecules promotes T cell receptor signal transduction

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4892427

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4892427

Other Identifiers

ISSN

0036-8075

E-ISSN

1095-9203

DOI

10.1126/science.aad9964

How to access this item