Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril
Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Amyloid fibrils are proteinaceous aggregates associated with diseases in humans and animals. The fibrils are defined by intermolecular interactions between the fibril-forming polypeptide chains, but it has so far remained difficult to reveal the assembly of the peptide subunits in a full-scale fibril. Using electron cryomicroscopy (cryo-EM), we pre...
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Full title
Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4896715
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4896715
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1522282113
