Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure
Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure
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Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: American Association for the Advancement of Science
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Contents
Dysfunction of microRNA (miRNA) metabolism is thought to underlie diseases affecting motoneurons. One miRNA, miR-218, is abundantly and selectively expressed by developing and mature motoneurons. Here we show that mutant mice lacking miR-218 die neonatally and exhibit neuromuscular junction defects, motoneuron hyperexcitability, and progressive mot...
Alternative Titles
Full title
Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4913787
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4913787
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aad2509
