Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
About this item
Full title
Author / Creator
Osteen, Jeremiah D. , Herzig, Volker , Gilchrist, John , Emrick, Joshua J. , Zhang, Chuchu , Wang, Xidao , Castro, Joel , Garcia-Caraballo, Sonia , Grundy, Luke , Rychkov, Grigori Y. , Weyer, Andy D. , Dekan, Zoltan , Undheim, Eivind A. B. , Alewood, Paul , Stucky, Cheryl L. , Brierley, Stuart M. , Basbaum, Allan I. , Bosmans, Frank , King, Glenn F. and Julius, David
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Voltage-gated sodium (Na
v
) channels initiate action potentials in most neurons, including primary afferent nerve fibres of the pain pathway. Local anaesthetics block pain through non-specific actions at all Na
v
channels, but the discovery of selective modulators would facilitate the analysis of individual subtypes of these channels a...
Alternative Titles
Full title
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
Authors, Artists and Contributors
Author / Creator
Herzig, Volker
Gilchrist, John
Emrick, Joshua J.
Zhang, Chuchu
Wang, Xidao
Castro, Joel
Garcia-Caraballo, Sonia
Grundy, Luke
Rychkov, Grigori Y.
Weyer, Andy D.
Dekan, Zoltan
Undheim, Eivind A. B.
Alewood, Paul
Stucky, Cheryl L.
Brierley, Stuart M.
Basbaum, Allan I.
Bosmans, Frank
King, Glenn F.
Julius, David
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4919188
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4919188
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature17976
