Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) as a therapeutic target to prevent retinal vasoper...
Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) as a therapeutic target to prevent retinal vasopermeability during diabetes
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) hydrolyses oxidized low-density lipoproteins into proinflammatory products, which can have detrimental effects on vascular function. As a specific inhibitor of Lp-PLA₂, darapladib has been shown to be protective against atherogenesis and vascular leakage in diabetic and hypercholesterolemic animal m...
Alternative Titles
Full title
Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) as a therapeutic target to prevent retinal vasopermeability during diabetes
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4932924
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4932924
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1514213113
