Ciprofloxacin blocked enterohepatic circulation of diclofenac and alleviated NSAID-induced enteropat...
Ciprofloxacin blocked enterohepatic circulation of diclofenac and alleviated NSAID-induced enteropathy in rats partly by inhibiting intestinal β-glucuronidase activity
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Author / Creator
Zhong, Ze-yu , Sun, Bin-bin , Shu, Nan , Xie, Qiu-shi , Tang, Xian-ge , Ling, Zhao-li , Wang, Fan , Zhao, Kai-jing , Xu, Ping , Zhang, Mian , Li, Ying , Chen, Yang , Liu, Li , Xia, Lun-zhu and Liu, Xiao-dong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Aim:
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID), which may cause serious intestinal adverse reactions (enteropathy). In this study we investigated whether co-administration of ciprofloxacin affected the pharmacokinetics of diclofenac and diclofenac-induced enteropathy in rats.
Methods:
The pharmacokinetics of diclofenac w...
Alternative Titles
Full title
Ciprofloxacin blocked enterohepatic circulation of diclofenac and alleviated NSAID-induced enteropathy in rats partly by inhibiting intestinal β-glucuronidase activity
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4933763
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4933763
Other Identifiers
ISSN
1671-4083
E-ISSN
1745-7254
DOI
10.1038/aps.2016.54
