Application of an in vitro-amplification assay as a novel pre-screening test for compounds inhibitin...
Application of an in vitro-amplification assay as a novel pre-screening test for compounds inhibiting the aggregation of prion protein scrapie
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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In vitro
amplification assays, such as real-time quaking-induced conversion (RT-QuIC) are used to detect aggregation activity of misfolded prion protein (PrP) in brain, cerebrospinal fluid (CSF) and urine samples from patients with a prion disease. We believe that the method also has a much broader application spectrum. In the present study, we...
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Application of an in vitro-amplification assay as a novel pre-screening test for compounds inhibiting the aggregation of prion protein scrapie
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4935936
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4935936
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep28711
