Interferon regulatory factor 3 is a key regulation factor for inducing the expression of SAMHD1 in a...
Interferon regulatory factor 3 is a key regulation factor for inducing the expression of SAMHD1 in antiviral innate immunity
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Author / Creator
Yang, Shen , Zhan, Yuan , Zhou, Yanjun , Jiang, Yifeng , Zheng, Xuchen , Yu, Lingxue , Tong, Wu , Gao, Fei , Li, Liwei , Huang, Qinfeng , Ma, Zhiyong and Tong, Guangzhi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
SAMHD1 is a type I interferon (IFN) inducible host innate immunity restriction factor that inhibits an early step of the viral life cycle. The underlying mechanisms of SAMHD1 transcriptional regulation remains elusive. Here, we report that inducing SAMHD1 upregulation is part of an early intrinsic immune response via TLR3 and RIG-I/MDA5 agonists th...
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Full title
Interferon regulatory factor 3 is a key regulation factor for inducing the expression of SAMHD1 in antiviral innate immunity
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4944147
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4944147
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep29665
