Targeting the RB-E2F pathway in breast cancer
Targeting the RB-E2F pathway in breast cancer
About this item
Full title
Author / Creator
Johnson, J , Thijssen, B , McDermott, U , Garnett, M , Wessels, L F A and Bernards, R
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mutations of the retinoblastoma tumor-suppressor gene (
RB1
) or components regulating the CDK-RB-E2F pathway have been identified in nearly every human malignancy. Re-establishing cell cycle control through cyclin-dependent kinase (CDK) inhibition has therefore emerged as an attractive option in the development of targeted cancer therapy. Th...
Alternative Titles
Full title
Targeting the RB-E2F pathway in breast cancer
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4950965
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4950965
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2016.32
