Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration
Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration
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Publisher
United States: American Society for Clinical Investigation
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Language
English
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United States: American Society for Clinical Investigation
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Contents
Aggregation of α-synuclein contributes to the formation of Lewy bodies and neurites, the pathologic hallmarks of Parkinson disease (PD) and α-synucleinopathies. Although a number of human mutations have been identified in familial PD, the mechanisms that promote α-synuclein accumulation and toxicity are poorly understood. Here, we report that hyper...
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Full title
Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4966315
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4966315
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ISSN
0021-9738,1558-8238
E-ISSN
1558-8238
DOI
10.1172/JCI85456
