Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
About this item
Full title
Author / Creator
Hegde, Meenakshi , Mukherjee, Malini , Grada, Zakaria , Pignata, Antonella , Landi, Daniel , Navai, Shoba A. , Wakefield, Amanda , Fousek, Kristen , Bielamowicz, Kevin , Chow, Kevin K.H. , Brawley, Vita S. , Byrd, Tiara T. , Krebs, Simone , Gottschalk, Stephen , Wels, Winfried S. , Baker, Matthew L. , Dotti, Gianpietro , Mamonkin, Maksim , Brenner, Malcolm K. , Orange, Jordan S. and Ahmed, Nabil
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
In preclinical models of glioblastoma, antigen escape variants can lead to tumor recurrence after treatment with CAR T cells that are redirected to single tumor antigens. Given the heterogeneous expression of antigens on glioblastomas, we hypothesized that a bispecific CAR molecule would mitigate antigen escape and improve the antitumor activity of...
Alternative Titles
Full title
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
Authors, Artists and Contributors
Author / Creator
Mukherjee, Malini
Grada, Zakaria
Pignata, Antonella
Landi, Daniel
Navai, Shoba A.
Wakefield, Amanda
Fousek, Kristen
Bielamowicz, Kevin
Chow, Kevin K.H.
Brawley, Vita S.
Byrd, Tiara T.
Krebs, Simone
Gottschalk, Stephen
Wels, Winfried S.
Baker, Matthew L.
Dotti, Gianpietro
Mamonkin, Maksim
Brenner, Malcolm K.
Orange, Jordan S.
Ahmed, Nabil
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4966331
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4966331
Other Identifiers
ISSN
0021-9738,1558-8238
E-ISSN
1558-8238
DOI
10.1172/JCI83416
