Local fitness landscape of the green fluorescent protein
Local fitness landscape of the green fluorescent protein
About this item
Full title
Author / Creator
Sarkisyan, Karen S. , Bolotin, Dmitry A. , Meer, Margarita V. , Usmanova, Dinara R. , Mishin, Alexander S. , Sharonov, George V. , Ivankov, Dmitry N. , Bozhanova, Nina G. , Baranov, Mikhail S. , Soylemez, Onuralp , Bogatyreva, Natalya S. , Vlasov, Peter K. , Egorov, Evgeny S. , Logacheva, Maria D. , Kondrashov, Alexey S. , Chudakov, Dmitry M. , Putintseva, Ekaterina V. , Mamedov, Ilgar Z. , Tawfik, Dan S. , Lukyanov, Konstantin A. and Kondrashov, Fyodor A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Comprehensive genotype–phenotype mapping of the green fluorescent protein shows that the local fitness peak is narrow, shaped by a high prevalence of epistatic interactions, providing for the loss of fluorescence when the joint effect of mutations exceeds a threshold.
Genotype to phenotype mapping of a model protein
Fyodor Kondrashov and coll...
Alternative Titles
Full title
Local fitness landscape of the green fluorescent protein
Authors, Artists and Contributors
Author / Creator
Bolotin, Dmitry A.
Meer, Margarita V.
Usmanova, Dinara R.
Mishin, Alexander S.
Sharonov, George V.
Ivankov, Dmitry N.
Bozhanova, Nina G.
Baranov, Mikhail S.
Soylemez, Onuralp
Bogatyreva, Natalya S.
Vlasov, Peter K.
Egorov, Evgeny S.
Logacheva, Maria D.
Kondrashov, Alexey S.
Chudakov, Dmitry M.
Putintseva, Ekaterina V.
Mamedov, Ilgar Z.
Tawfik, Dan S.
Lukyanov, Konstantin A.
Kondrashov, Fyodor A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4968632
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4968632
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature17995
