Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and pro...
Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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ALOX15 (12/15-lipoxygenase) orthologs have been implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids. Here we hypothesized that lower mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologs. In contrast, 15-lipoxygenating isoforms are found in highe...
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Full title
Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4968705
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4968705
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1604029113
