Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving d...
Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
About this item
Full title
Author / Creator
Guaitoli, Giambattista , Raimondi, Francesco , Gilsbach, Bernd K. , Gómez-Llorente, Yacob , Deyaert, Egon , Renzi, Fabiana , Li, Xianting , Schaffner, Adam , Jagtap, Pravin Kumar Ankush , Boldt, Karsten , von Zweydorf, Felix , Gotthardt, Katja , Lorimer, Donald D. , Yue, Zhenyu , Burgin, Alex , Janjic, Nebojsa , Sattler, Michael , Versées, Wim , Ueffing, Marius , Ubarretxena-Belandia, Iban , Kortholt, Arjan and Gloeckner, Christian Johannes
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein containing two catalytic domains: a Ras of complex proteins (Roc) G-domain and a kinase domain. Mutations associated with familial and sporadic Parkinson’s disease (PD) have been identified in both catalytic domains, as well as in several of its multiple putative regulatory domain...
Alternative Titles
Full title
Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
Authors, Artists and Contributors
Author / Creator
Raimondi, Francesco
Gilsbach, Bernd K.
Gómez-Llorente, Yacob
Deyaert, Egon
Renzi, Fabiana
Li, Xianting
Schaffner, Adam
Jagtap, Pravin Kumar Ankush
Boldt, Karsten
von Zweydorf, Felix
Gotthardt, Katja
Lorimer, Donald D.
Yue, Zhenyu
Burgin, Alex
Janjic, Nebojsa
Sattler, Michael
Versées, Wim
Ueffing, Marius
Ubarretxena-Belandia, Iban
Kortholt, Arjan
Gloeckner, Christian Johannes
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4968714
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4968714
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1523708113
