Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau
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Publisher
Berlin/Heidelberg: Springer-Verlag
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Language
English
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Berlin/Heidelberg: Springer-Verlag
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Neurofibrillary lesions of abnormal Tau are hallmarks of Alzheimer disease and frontotemporal dementias. Our regulatable (Tet-OFF) mouse models of tauopathy express variants of human full-length Tau in the forebrain (CaMKIIα promoter) either with mutation ΔK280 (pro-aggregant) or ΔK280/I277P/I308P (anti-aggregant). Co-expression of luciferase enabl...
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Full title
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4979687
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4979687
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-012-0987-3
