Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural i...
Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Increasing evidence supports a role for abnormal immune activation and inflammatory responses in Huntington disease (HD). In this study, we evaluated the therapeutic potential of laquinimod (1 and 10 mg/kg), a novel immunomodulatory agent shown to be protective in a number of neuroinflammatory conditions, in the YAC128 mouse model of HD. Treatment...
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Full title
Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4985819
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4985819
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep31652
