Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease
Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
In Parkinson’s disease, misfolded α-synuclein accumulates, often in a ubiquitinated form, in neuronal inclusions termed Lewy bodies. An important outstanding question is whether ubiquitination in Lewy bodies is directly relevant to α-synuclein trafficking or turnover and Parkinson’s pathogenesis. By comparative analysis in human postmortem brains,...
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Full title
Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4987833
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4987833
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1523597113
