Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Structural data on the protein CASTOR1 reveal how the mTORC1 pathway senses intracellular arginine, suggesting a repurposing of an evolutionarily pre-metazoan mechanism.
Structure of human CASTOR1 bound to arginine
The mTOR pathway is a major regulator of cell growth and is deregulated in numerous diseases. It is influenced by various environ...
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Full title
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4988899
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4988899
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature19079
