Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1
Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1
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Author / Creator
Garcia-Beltran, Wilfredo F , Hölzemer, Angelique , Martrus, Gloria , Chung, Amy W , Pacheco, Yovana , Simoneau, Camille R , Rucevic, Marijana , Lamothe-Molina, Pedro A , Pertel, Thomas , Kim, Tae-Eun , Dugan, Haley , Alter, Galit , Dechanet-Merville, Julie , Jost, Stephanie , Carrington, Mary and Altfeld, Marcus
Publisher
New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Contents
The activating NK cell receptor KIR3DS1 has been linked to the outcome of various human diseases, yet a ligand that would account for its biological effects has remained unknown. Altfeld and colleagues establish HLA-F as a ligand of KIR3DS1, which helps to explain the widespread influence of this receptor in disease.
The activating natural kille...
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Full title
Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4992421
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4992421
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ISSN
1529-2908,1529-2916
E-ISSN
1529-2916
DOI
10.1038/ni.3513
