Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
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Author / Creator
Chu, Hiutung , Khosravi, Arya , Kusumawardhani, Indah P. , Kwon, Alice H. K. , Vasconcelos, Anilton C. , Cunha, Larissa D. , Mayer, Anne E. , Shen, Yue , Wu, Wei-Li , Kambal, Amal , Targan, Stephan R. , Xavier, Ramnik J. , Ernst, Peter B. , Green, Douglas R. , McGovern, Dermot P. B. , Virgin, Herbert W. and Mazmanian, Sarkis K.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: American Association for the Advancement of Science
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Scope and Contents
Contents
Inflammatory bowel disease (IBD) is associated with risk variants in the human genome and dysbiosis of the gut microbiome, though unifying principles for these findings remain largely undescribed. The human commensal Bacteroides fragilis delivers immunomodulatory molecules to immune cells via secretion of outer membrane vesicles (OMVs). We reveal t...
Alternative Titles
Full title
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4996125
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4996125
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aad9948
