HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential thera...
HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease
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Author / Creator
Fujita, Kyota , Motoki, Kazumi , Tagawa, Kazuhiko , Chen, Xigui , Hama, Hiroshi , Nakajima, Kazuyuki , Homma, Hidenori , Tamura, Takuya , Watanabe, Hirohisa , Katsuno, Masahisa , Matsumi, Chiemi , Kajikawa, Masunori , Saito, Takashi , Saido, Takaomi , Sobue, Gen , Miyawaki, Atsushi and Okazawa, Hitoshi
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Alzheimer’s disease (AD) is the most common neurodegenerative disease, but it remains an intractable condition. Its pathogenesis is predominantly attributed to the aggregation and transmission of two molecules, Aβ and tau; however, other pathological mechanisms are possible. Here, we reveal that phosphorylation of MARCKS, a submembrane protein that...
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Full title
HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4997258
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4997258
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep31895
