HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Size-selective pores in the HIV-1 capsid hexamer recruit nucleotides, thereby allowing reverse transcription to take place inside the capsid.
Capsid pores key to HIV-1 proliferation
Recent work has suggested that HIV-1 evades innate DNA sensors such as cGAS by enclosing the viral genome inside a protective protein shell, the capsid. If the vi...
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Full title
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4998957
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4998957
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature19098
