Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabo...
Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabolite-I, in immune cells simulating mevalonate kinase deficiency (MKD)-like condition
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Cham: Springer International Publishing
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Language
English
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Cham: Springer International Publishing
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Contents
TAK-475 (lapaquistat acetate) and its active metabolite-I (TAK-475 M-I) inhibit squalene synthase, which catalyzes the conversion of farnesyl diphosphate (FPP) to squalene. FPP is a substrate for synthesis of other mevalonate-derived isoprenoids (MDIs) such as farnesol (FOH), geranlygeranyl diphosphate (GGPP), and geranylgeraniol. In patients with...
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Full title
Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabolite-I, in immune cells simulating mevalonate kinase deficiency (MKD)-like condition
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5005254
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5005254
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ISSN
2193-1801
E-ISSN
2193-1801
DOI
10.1186/s40064-016-3125-1
