NOTCH1 mediates a switch between two distinct secretomes during senescence
NOTCH1 mediates a switch between two distinct secretomes during senescence
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced senescence is accompanied by a dynamic fluctuation of NOTCH1 activity, which drives a TGF-β-rich secretome, while suppressing the...
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Full title
NOTCH1 mediates a switch between two distinct secretomes during senescence
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5008465
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5008465
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3397
