Identification of oncogenic driver mutations by genome-wide CRISPR-Cas9 dropout screening
Identification of oncogenic driver mutations by genome-wide CRISPR-Cas9 dropout screening
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Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Genome-wide CRISPR-Cas9 dropout screens can identify genes whose knockout affects cell viability. Recent CRISPR screens detected thousands of essential genes required for cellular survival and key cellular processes; however discovering novel lineage-specific genetic dependencies from the many hits still remains a challenge.
To assess whether CR...
Alternative Titles
Full title
Identification of oncogenic driver mutations by genome-wide CRISPR-Cas9 dropout screening
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5016932
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5016932
Other Identifiers
ISSN
1471-2164
E-ISSN
1471-2164
DOI
10.1186/s12864-016-3042-2
