Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Small unilamellar vesicles composed of the negatively charged lipid DMPS enhance the aggregation of the Lewy Body disease protein α-synuclein by increasing the rate of primary nucleation by a thousandfold.
α-Synuclein (α-syn) is a 140-residue intrinsically disordered protein that is involved in neuronal and synaptic vesicle plasticity, but its a...
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Full title
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5019199
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5019199
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1750
