Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in ne...
Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
The protease BACE1 (beta-site APP cleaving enzyme) is a major drug target in Alzheimer's disease. However, BACE1 therapeutic inhibition may cause unwanted adverse effects due to its additional functions in the nervous system, such as in myelination and neuronal connectivity. Additionally, recent proteomic studies investigating BACE1 inhibition in c...
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Full title
Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5053352
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5053352
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-016-0134-z
