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Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-d...

Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-d...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5072445

Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility

About this item

Full title

Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility

Publisher

London: Nature Publishing Group UK

Journal title

Cell death and differentiation, 2016-03, Vol.23 (3), p.521-530

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Beside its well-documented role in carcinogenesis, the function of p53 family has been more recently revealed in development and female reproduction, but it is still poorly documented in male reproduction. We specifically tested this possibility by ablating Mdm2, an E3 ligase that regulates p53 protein stability and transactivation function, specif...

Alternative Titles

Full title

Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5072445

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5072445

Other Identifiers

ISSN

1350-9047,1476-5403

E-ISSN

1476-5403

DOI

10.1038/cdd.2015.120

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