Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain
Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain
About this item
Full title
Author / Creator
Sisignano, Marco , Angioni, Carlo , Park, Chul-Kyu , Dos Santos, Sascha Meyer , Jordan, Holger , Kuzikov, Maria , Liu, Di , Zinn, Sebastian , Hohman, Stephan W. , Schreiber, Yannick , Zimmer, Béla , Schmidt, Mike , Lu, Ruirui , Suo, Jing , Zhang, Dong-Dong , Schäfer, Stephan M. G. , Hofmann, Martine , Yekkirala, Ajay S. , de Bruin, Natasja , Parnham, Michael J. , Woolf, Clifford J. , Ji, Ru-Rong , Scholich, Klaus and Geisslinger, Gerd
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a severe dose- and therapy-limiting side effect of widely used cytostatics that is particularly difficult to treat. Here, we report increased expression of the cytochrome-P450-epoxygenase CYP2J6 and increased concentrations of its linoleic acid metabolite 9,10-EpOME (9,10-epoxy-12Z-octadec...
Alternative Titles
Full title
Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain
Authors, Artists and Contributors
Author / Creator
Angioni, Carlo
Park, Chul-Kyu
Dos Santos, Sascha Meyer
Jordan, Holger
Kuzikov, Maria
Liu, Di
Zinn, Sebastian
Hohman, Stephan W.
Schreiber, Yannick
Zimmer, Béla
Schmidt, Mike
Lu, Ruirui
Suo, Jing
Zhang, Dong-Dong
Schäfer, Stephan M. G.
Hofmann, Martine
Yekkirala, Ajay S.
de Bruin, Natasja
Parnham, Michael J.
Woolf, Clifford J.
Ji, Ru-Rong
Scholich, Klaus
Geisslinger, Gerd
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5098623
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5098623
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1613246113
