Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing
Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing
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Publisher
United States: Elsevier Inc
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Language
English
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Publisher
United States: Elsevier Inc
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Scope and Contents
Contents
Delivery represents a significant barrier to the clinical advancement of oligonucleotide therapeutics for the treatment of neurological disorders, such as Huntington's disease. Small, endogenous vesicles known as exosomes have the potential to act as oligonucleotide delivery vehicles, but robust and scalable methods for loading RNA therapeutic carg...
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Full title
Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5112038
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5112038
Other Identifiers
ISSN
1525-0016
E-ISSN
1525-0024
DOI
10.1038/mt.2016.126
