Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Sympt...
Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model
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Author / Creator
Ghoshal, A , Rook, J M , Dickerson, J W , Roop, G N , Morrison, R D , Jalan-Sakrikar, N , Lamsal, A , Noetzel, M J , Poslusney, M S , Wood, M R , Melancon, B J , Stauffer, S R , Xiang, Z , Daniels, J S , Niswender, C M , Jones, C K , Lindsley, C W and Conn, P J
Publisher
England: Nature Publishing Group
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English
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Publisher
England: Nature Publishing Group
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Contents
Schizophrenia patients exhibit deficits in signaling of the M1 subtype of muscarinic acetylcholine receptor (mAChR) in the prefrontal cortex (PFC) and also display impaired cortical long-term depression (LTD). We report that selective activation of the M1 mAChR subtype induces LTD in PFC and that this response is completely lost after repeated admi...
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Full title
Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5130135
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5130135
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ISSN
0893-133X
E-ISSN
1740-634X
DOI
10.1038/npp.2015.189
