A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
About this item
Full title
Author / Creator
Wang, Yingfei , An, Ran , Umanah, George K. , Park, Hyejin , Nambiar, Kalyani , Eacker, Stephen M. , Kim, BongWoo , Bao, Lei , Harraz, Maged M. , Chang, Calvin , Chen, Rong , Wang, Jennifer E. , Kam, Tae-In , Jeong, Jun Seop , Xie, Zhi , Neifert, Stewart , Qian, Jiang , Andrabi, Shaida A. , Blackshaw, Seth , Zhu, Heng , Song, Hongjun , Ming, Guo-li , Dawson, Valina L. and Dawson, Ted M.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Cells that experience stresses and accumulate excessive damage to DNA undergo cell death mediated by a nuclear enzyme known as PARP-1. During this process, apoptosis-inducing factor (AIF) translocates to the nucleus and activates one or more nucleases to cleave DNA. Wang
et al.
found that macrophage migration inhibitory factor (MIF) is an AIF...
Alternative Titles
Full title
A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
Authors, Artists and Contributors
Author / Creator
An, Ran
Umanah, George K.
Park, Hyejin
Nambiar, Kalyani
Eacker, Stephen M.
Kim, BongWoo
Bao, Lei
Harraz, Maged M.
Chang, Calvin
Chen, Rong
Wang, Jennifer E.
Kam, Tae-In
Jeong, Jun Seop
Xie, Zhi
Neifert, Stewart
Qian, Jiang
Andrabi, Shaida A.
Blackshaw, Seth
Zhu, Heng
Song, Hongjun
Ming, Guo-li
Dawson, Valina L.
Dawson, Ted M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5134926
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5134926
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aad6872
