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A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5134926

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

About this item

Full title

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

Publisher

United States: American Association for the Advancement of Science

Journal title

Science (American Association for the Advancement of Science), 2016-10, Vol.354 (6308), p.82-82

Language

English

Formats

Publication information

Publisher

United States: American Association for the Advancement of Science

More information

Scope and Contents

Contents

Cells that experience stresses and accumulate excessive damage to DNA undergo cell death mediated by a nuclear enzyme known as PARP-1. During this process, apoptosis-inducing factor (AIF) translocates to the nucleus and activates one or more nucleases to cleave DNA. Wang
et al.
found that macrophage migration inhibitory factor (MIF) is an AIF...

Alternative Titles

Full title

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5134926

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5134926

Other Identifiers

ISSN

0036-8075

E-ISSN

1095-9203

DOI

10.1126/science.aad6872

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