BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence
BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence
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Author / Creator
Hayashi, Yohei , Hsiao, Edward C. , Sami, Salma , Lancero, Mariselle , Schlieve, Christopher R. , Nguyen, Trieu , Yano, Koyori , Nagahashi, Ayako , Ikeya, Makoto , Matsumoto, Yoshihisa , Nishimura, Ken , Fukuda, Aya , Hisatake, Koji , Tomoda, Kiichiro , Asaka, Isao , Toguchida, Junya , Conklin, Bruce R. and Yamanaka, Shinya
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Fibrodysplasia ossificans progressiva (FOP) patients carry a missense mutation in ACVR1 [617G > A (R206H)] that leads to hyperactivation of BMP-SMAD signaling. Contrary to a previous study, here we show that FOP fibroblasts showed an increased efficiency of induced pluripotent stem cell (iPSC) generation. This positive effect was attenuated by inhi...
Alternative Titles
Full title
BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5135304
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5135304
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1603668113
