SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity
SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The 3C-like protease (3CLpro) of severe acute respiratory syndrome coronavirus (SARS-CoV) cleaves 11 sites in the polyproteins, including its own N- and C-terminal autoprocessing sites, by recognizing P4–P1 and P1′. In this study, we determined the crystal structure of 3CLpro with the C-terminal prosequence and the catalytic-site C145A mutation, in...
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Full title
SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5135343
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5135343
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1601327113
