Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization
Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Members of the p53 tumor-suppressor family are expressed as multiple isoforms. Isoforms with an N-terminal transactivation domain are transcriptionally active, while those ones lacking this domain often inhibit the transcriptional activity of other family members. In squamous cell carcinomas, the high expression level of ΔNp63
α
inhibits the...
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Full title
Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5136491
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5136491
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/cdd.2016.83
