Structure-based discovery of opioid analgesics with reduced side effects
Structure-based discovery of opioid analgesics with reduced side effects
About this item
Full title
Author / Creator
Manglik, Aashish , Lin, Henry , Aryal, Dipendra K. , McCorvy, John D. , Dengler, Daniela , Corder, Gregory , Levit, Anat , Kling, Ralf C. , Bernat, Viachaslau , Hübner, Harald , Huang, Xi-Ping , Sassano, Maria F. , Giguère, Patrick M. , Löber, Stefan , Da Duan , Scherrer, Grégory , Kobilka, Brian K. , Gmeiner, Peter , Roth, Bryan L. and Shoichet, Brian K.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Morphine is an alkaloid from the opium poppy used to treat pain. The potentially lethal side effects of morphine and related opioids—which include fatal respiratory depression—are thought to be mediated by μ-opioid-receptor (μOR) signalling through the β-arrestin pathway or by actions at other receptors. Conversely, G-protein μOR signalling is thou...
Alternative Titles
Full title
Structure-based discovery of opioid analgesics with reduced side effects
Authors, Artists and Contributors
Author / Creator
Lin, Henry
Aryal, Dipendra K.
McCorvy, John D.
Dengler, Daniela
Corder, Gregory
Levit, Anat
Kling, Ralf C.
Bernat, Viachaslau
Hübner, Harald
Huang, Xi-Ping
Sassano, Maria F.
Giguère, Patrick M.
Löber, Stefan
Da Duan
Scherrer, Grégory
Kobilka, Brian K.
Gmeiner, Peter
Roth, Bryan L.
Shoichet, Brian K.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5161585
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5161585
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature19112
