Combined copy number and mutation analysis identifies oncogenic pathways associated with transformat...
Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma
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Author / Creator
Bouska, A , Zhang, W , Gong, Q , Iqbal, J , Scuto, A , Vose, J , Ludvigsen, M , Fu, K , Weisenburger, D D , Greiner, T C , Gascoyne, R D , Rosenwald, A , Ott, G , Campo, E , Rimsza, L M , Delabie, J , Jaffe, E S , Braziel, R M , Connors, J M , Wu, C-I , Staudt, L M , D‘Amore, F , McKeithan, T W and Chan, W C
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Follicular lymphoma (FL) is typically an indolent disease, but 30–40% of FL cases transform into an aggressive lymphoma (tFL) with a poor prognosis. To identify the genetic changes that drive this transformation, we sequenced the exomes of 12 cases with paired FL and tFL biopsies and identified 45 recurrently mutated genes in the FL–tFL data set an...
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Full title
Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5214175
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5214175
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2016.175
