SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate can...
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer
About this item
Full title
Author / Creator
Mu, Ping , Zhang, Zeda , Benelli, Matteo , Karthaus, Wouter R. , Hoover, Elizabeth , Chen, Chi-Chao , Wongvipat, John , Ku, Sheng-Yu , Gao, Dong , Cao, Zhen , Shah, Neel , Adams, Elizabeth J. , Abida, Wassim , Watson, Philip A. , Prandi, Davide , Huang, Chun-Hao , de Stanchina, Elisa , Lowe, Scott W. , Ellis, Leigh , Beltran, Himisha , Rubin, Mark A. , Goodrich, David W. , Demichelis, Francesca and Sawyers, Charles L.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Some cancers evade targeted therapies through a mechanism known as lineage plasticity, whereby tumor cells acquire phenotypic characteristics of a cell lineage whose survival no longer depends on the drug target. We use in vitro and in vivo human prostate cancer models to show that these tumors can develop resistance to the antiandrogen drug enzalu...
Alternative Titles
Full title
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer
Authors, Artists and Contributors
Author / Creator
Zhang, Zeda
Benelli, Matteo
Karthaus, Wouter R.
Hoover, Elizabeth
Chen, Chi-Chao
Wongvipat, John
Ku, Sheng-Yu
Gao, Dong
Cao, Zhen
Shah, Neel
Adams, Elizabeth J.
Abida, Wassim
Watson, Philip A.
Prandi, Davide
Huang, Chun-Hao
de Stanchina, Elisa
Lowe, Scott W.
Ellis, Leigh
Beltran, Himisha
Rubin, Mark A.
Goodrich, David W.
Demichelis, Francesca
Sawyers, Charles L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5247742
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5247742
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aah4307
