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Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immun...

Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immun...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5255606

Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity

About this item

Full title

Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (3), p.E396-E405

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Astrocytes are believed to bridge interactions between infiltrating lymphocytes and neurons during brain ischemia, but the mechanisms for this action are poorly understood. Here we found that interleukin-15 (IL-15) is dramatically up-regulated in astrocytes of postmortem brain tissues from patients with ischemic stroke and in a mouse model of trans...

Alternative Titles

Full title

Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5255606

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5255606

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1612930114

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