Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling
Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The tumor suppressor protein Merlin is proteasomally degraded in breast cancer. We undertook an untargeted metabolomics approach to discern the global metabolomics profile impacted by Merlin in breast cancer cells. We discerned specific changes in glutathione metabolites that uncovered novel facets of Merlin in impacting the cancer cell metabolome....
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Full title
Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5256100
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5256100
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep40773
