Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated sub...
Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment
About this item
Full title
Author / Creator
Kai, Yugo , Hikita, Hayato , Morishita, Naoki , Murai, Kazuhiro , Nakabori, Tasuku , Iio, Sadaharu , Hagiwara, Hideki , Imai, Yasuharu , Tamura, Shinji , Tsutsui, Syusaku , Naito, Masafumi , Nishiuchi, Meiko , Kondo, Yasuteru , Kato, Takanobu , Suemizu, Hiroshi , Yamada, Ryoko , Oze, Tsugiko , Yakushijin, Takayuki , Hiramatsu, Naoki , Sakamori, Ryotaro , Tatsumi, Tomohide and Takehara, Tetsuo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Resistance-associated substitutions (RASs) in hepatitis C virus (HCV) appear upon failure of treatment with direct-acting antivirals (DAAs). However, their origin has not been clarified in detail. Among 11 HCV genotype 1b patients who experienced virologic failure with asunaprevir (ASV)/daclatasvir (DCV), 10 had major NS5A L31M/V-Y93H variants afte...
Alternative Titles
Full title
Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment
Authors, Artists and Contributors
Author / Creator
Hikita, Hayato
Morishita, Naoki
Murai, Kazuhiro
Nakabori, Tasuku
Iio, Sadaharu
Hagiwara, Hideki
Imai, Yasuharu
Tamura, Shinji
Tsutsui, Syusaku
Naito, Masafumi
Nishiuchi, Meiko
Kondo, Yasuteru
Kato, Takanobu
Suemizu, Hiroshi
Yamada, Ryoko
Oze, Tsugiko
Yakushijin, Takayuki
Hiramatsu, Naoki
Sakamori, Ryotaro
Tatsumi, Tomohide
Takehara, Tetsuo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5278351
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5278351
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep41660
