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CD34⁺ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and...

CD34⁺ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5278455

CD34⁺ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury

About this item

Full title

CD34⁺ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (4), p.E506-E513

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

The intestinal epithelium is continuously renewed by intestinal epithelial stem cells (IESCs) positioned at the base of each crypt. Mesenchymal-derived factors are essential to maintain IESCs; however, the cellular composition and development of such mesenchymal niche remains unclear. Here, we identify pericryptal CD34⁺ Gp38⁺ αSMA⁻ mesenchymal cell...

Alternative Titles

Full title

CD34⁺ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5278455

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5278455

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1620059114

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