Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate
Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate
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Author / Creator
Chaturvedi, A , Araujo Cruz, M M , Jyotsana, N , Sharma, A , Goparaju, R , Schwarzer, A , Görlich, K , Schottmann, R , Struys, E A , Jansen, E E , Rohde, C , Müller-Tidow, C , Geffers, R , Göhring, G , Ganser, A , Thol, F and Heuser, M
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Canonical mutations in
IDH1
and
IDH2
produce high levels of the
R
-enantiomer of 2-hydroxyglutarate (
R
-2HG), which is a competitive inhibitor of α-ketoglutarate (αKG)-dependent enzymes and a putative oncometabolite. Mutant IDH1 collaborates with HoxA9 to induce monocytic leukemia
in vivo
. We used two mouse models an...
Alternative Titles
Full title
Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5298178
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5298178
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2016.71
