Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity
Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity
About this item
Full title
Author / Creator
Turner, Kristen M. , Deshpande, Viraj , Beyter, Doruk , Koga, Tomoyuki , Rusert, Jessica , Lee, Catherine , Li, Bin , Arden, Karen , Ren, Bing , Nathanson, David A. , Kornblum, Harley I. , Taylor, Michael D. , Kaushal, Sharmeela , Cavenee, Webster K. , Wechsler-Reya, Robert , Furnari, Frank B. , Vandenberg, Scott R. , Rao, P. Nagesh , Wahl, Geoffrey M. , Bafna, Vineet and Mischel, Paul S.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Circular extrachromosomal DNA is found in nearly half of human cancers of a wide variety of histologic types, increasing the copy number of driver oncogenes and intratumoral heterogeneity more effectively than chromosomal amplification and contributing to tumor evolution.
Extrachromosomal DNA in cancer evolution
Extrachromosomal DNA has been...
Alternative Titles
Full title
Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity
Authors, Artists and Contributors
Author / Creator
Deshpande, Viraj
Beyter, Doruk
Koga, Tomoyuki
Rusert, Jessica
Lee, Catherine
Li, Bin
Arden, Karen
Ren, Bing
Nathanson, David A.
Kornblum, Harley I.
Taylor, Michael D.
Kaushal, Sharmeela
Cavenee, Webster K.
Wechsler-Reya, Robert
Furnari, Frank B.
Vandenberg, Scott R.
Rao, P. Nagesh
Wahl, Geoffrey M.
Bafna, Vineet
Mischel, Paul S.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5334176
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5334176
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature21356
