GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
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Author / Creator
Lo, Michael K. , Jordan, Robert , Arvey, Aaron , Sudhamsu, Jawahar , Shrivastava-Ranjan, Punya , Hotard, Anne L. , Flint, Mike , McMullan, Laura K. , Siegel, Dustin , Clarke, Michael O. , Mackman, Richard L. , Hui, Hon C. , Perron, Michel , Ray, Adrian S. , Cihlar, Tomas , Nichol, Stuart T. and Spiropoulou, Christina F.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been administered under compassionate use to two Ebola patients, both of whom survived, and is currently in Phase 2 clinical development for treatment of Ebola virus disease. Here we rep...
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Full title
GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5338263
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5338263
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep43395
