Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatm...
Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy
About this item
Full title
Author / Creator
Woo, Caroline J. , Maier, Verena K. , Davey, Roshni , Brennan, James , Li, Guangde , Brothers, John , Schwartz, Brian , Gordo, Susana , Kasper, Anne , Okamoto, Trevor R. , Johansson, Hans E. , Mandefro, Berhan , Sareen, Dhruv , Bialek, Peter , Chau, B. Nelson , Bhat, Balkrishen , Bullough, David and Barsoum, James
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by progressive motor neuron loss and caused by mutations in SMN1 (Survival Motor Neuron 1). The disease severity inversely correlates with the copy number of SMN2, a duplicated gene that is nearly identical to SMN1. We have delineated a mechanism of transcriptional regulatio...
Alternative Titles
Full title
Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5338378
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5338378
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1616521114
