Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice
Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice
About this item
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Author / Creator
Zhang, R , Asai, M , Mahoney, C E , Joachim, M , Shen, Y , Gunner, G and Majzoub, J A
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
A long-standing paradigm posits that hypothalamic corticotropin-releasing hormone (CRH) regulates neuroendocrine functions such as adrenal glucocorticoid release, whereas extra-hypothalamic CRH has a key role in stressor-triggered behaviors. Here we report that hypothalamus-specific
Crh
knockout mice (
Sim1CrhKO
mice, created by crossin...
Alternative Titles
Full title
Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5339066
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5339066
Other Identifiers
ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/mp.2016.136
